Disconnection of network hubs and cognitive impairment after traumatic brain injury

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Disconnection of network hubs and cognitive impairment after traumatic brain injury

Traumatic brain injury affects brain connectivity by producing traumatic axonal injury. This disrupts the function of large-scale networks that support cognition. The best way to describe this relationship is unclear, but one elegant approach is to view networks as graphs. Brain regions become nodes in the graph, and white matter tracts the connections. The overall effect of an injury can then ...

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White matter damage and cognitive impairment after traumatic brain injury

White matter disruption is an important determinant of cognitive impairment after brain injury, but conventional neuroimaging underestimates its extent. In contrast, diffusion tensor imaging provides a validated and sensitive way of identifying the impact of axonal injury. The relationship between cognitive impairment after traumatic brain injury and white matter damage is likely to be complex....

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OBJECTIVE The aim of this study was to explore the relationship between the proteins S100B and S100A1B and symptoms and signs of cognitive impairment for 3 months after mild traumatic brain injury (MTBI). METHODS Serum concentrations of S100A1B and S100B were examined in a prospective cohort study of patients with MTBI and a Glasgow Coma Scale score of 14 or 15. Cognitive performance was asse...

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pituitary function impairment after moderate traumatic brain injury

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Cognitive problems after traumatic brain injury.

How family members can help: Use kind words and a gentle tone of voice. Be careful not to “talk down” to the person. When talking with the injured person, ask every so often if he or she understands what you are saying. Do not speak too fast or say too much at once. Develop a signal that will let the injured person know when he or she has gotten off-topic. Limit conversations to 1 person at a t...

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ژورنال

عنوان ژورنال: Brain

سال: 2015

ISSN: 0006-8950,1460-2156

DOI: 10.1093/brain/awv075